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Background Patient prognosis and response to endocrine therapy in breast cancer correlate with protein expression of both estrogen receptor (ER) and progesterone receptor (PR), with poorer outcome in patients with ER+/PR− compared to ER+/PR+ tumors. Methods To better understand the underlying biology of ER+/PR− tumors, we examined RNA expression (n > 1000 tumors) and DNA copy number profiles from...
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