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Insulin-like growth factors (IGF-1 and IGF-2) are necessary for normal growth and development. They are related structurally to proinsulin and promote cell proliferation, differentiation, and survival, as well as insulin-like metabolic effects, in most cell types and tissues. In particular, IGFs are important for normal pre- and postnatal kidney development. IGF-1 mediates many growth hormone actions,...
AimMouse chow is commonly high in advanced glycation end‐products, known contributors to diabetic nephropathy. The aim of this study was to evaluate if targeting of the AGE‐RAGE axis was still effective in the context of a diet low in AGE content, which is more comparable to diets consumed by individuals with type 1 diabetes.
MethodsC57BL/6J wild‐type and mice deficient in the receptor for AGEs (RAGE‐KO)...
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