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Programmed cell death protein 1 (PD‐1) is an immunoregulatory target which is recognized by different monoclonal antibodies, approved for the therapy of multiple types of cancer. Different anti‐PD‐1 antibodies display different therapeutic properties and there is a pharmaceutical interest to generate and characterize novel anti‐PD‐1 antibodies. We screened multiple human antibody phage display libraries...
We describe the cloning and characterization of a novel fusion protein (termed L19‐mIL12), consisting of murine interleukin‐12 in single‐chain format, sequentially fused to the L19 antibody in tandem diabody format. The fusion protein bound avidly to the cognate antigen (the alternatively spliced EDB domain of fibronectin), retained the activity of the parental cytokine and was able to selectively...
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