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The roles of ion channels in sensory neurons were examined in experimental models of muscle pain in the rat. Rats were injected with 50μl of 4% carrageenan or subjected to an eccentric exercise (ECC) of the gastrocnemius muscle (GM). The Randall–Selitto and von Frey tests were performed on the calves to evaluate mechanical hyperalgesia of the muscle. The changes in expression of four genes and proteins...
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