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The combination of I Kr and I Ks blockade could lead to synergistic and safe class III anti-arrhythmic effect with the enhanced efficacy and reduced risk. On the rationale of structural hybridization of azimilide and HMR-1556, a novel series of I Kr and I Ks dual blockers were designed, synthesized and evaluated in vitro. One compound, 3r (CPUY11018), deserves further...
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