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The mammalian multifunctional protein-2 (MFP-2, also called multifunctional enzyme 2, D-bifunctional enzyme or 17-β-estradiol dehydrogenase type IV) was identified by several groups about a decade ago. It plays a central role in peroxisomal β-oxidation as it handles most, if not all, peroxisomal β-oxidation substrates. Deficiency of this enzyme in man causes a severe developmental syndrome with abnormalities...
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