Search results for: Ki Taek Nam

Items from 1 to 20 out of 77 results

article

RAB25 coordinates filaggrin‐containing keratohyalin granule maturation and affects atopic dermatitis severity

Haengdueng Jeong, Nakyum Lee, Chanyang Uhm, Kyungrae Cho, more

Allergy > 78 > 4 > 1007 - 1019

Background Keratohyalin granules (KHGs) supply the critical epidermal protein constituents such as filaggrin for maintaining skin barrier function during epidermal differentiation; however, their regulating mechanism remains largely unelucidated. Methods To investigate the role of Ras‐related protein Rab‐25 (RAB25) expression in skin disease, we utilized skin specimens of patients with moderate‐to‐severe...

article

Reactivity Differences Enable ROS for Selective Ablation of Bacteria

Xiaofeng Wu, Mengyao Yang, Ji Seon Kim, Rui Wang, more

Angewandte Chemie International Edition > 61 > 17 > n/a - n/a

An effective strategy to engineer selective photodynamic agents to surmount bacterial‐infected diseases, especially Gram‐positive bacteria remains a great challenge. Herein, we developed two examples of compounds for a proof‐of‐concept study where reactive differences in reactive oxygen species (ROS) can induce selective ablation of Gram‐positive bacteria. Sulfur‐replaced phenoxazinium (NBS‐N) mainly...

article

Reactivity Differences Enable ROS for Selective Ablation of Bacteria

Xiaofeng Wu, Mengyao Yang, Ji Seon Kim, Rui Wang, more

Angewandte Chemie > 134 > 17 > n/a - n/a

article

Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking

Haengdueng Jeong, Kyung‐Min Lim, Kwang H Kim, Yejin Cho, more

The Journal of Pathology > 249 > 2 > 227 - 240

Rab25 can function as both a tumor suppressor and a tumor promoter across different tissues. This study sought to clarify the role of Rab25 as a tumor suppressor in skin squamous cell carcinoma (SCC). Rab25 loss was closely associated with neoplastic transition in both humans and mice. Rab25 loss was well correlated with increased cell proliferation and poor differentiation in human SCC. While Rab25...

article

Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine

Jin Sun You, Ji Hyun Yong, Gwang Hee Kim, Sungmin Moon, more

Microbiome > 2019 > 7 > 1 > 1-18

Background Recent evidence suggests that the commensal microbes act as a barrier against invading pathogens and enteric infections are the consequences of multi-layered interactions among commensals, pathogens, and the host intestinal tissue. However, it remains unclear how perturbations of the gut microbiota compromise host infection resistance, especially through changes at species and metabolite...

article

ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome

Ah-Reum Oh, Seonyong Sohn, Junghoon Lee, Jong-Min Park, more

Metabolism > 2018 > 85 > C > 286-297

Fructose malabsorption is a common digestive disorder in which absorption of fructose in the small intestine is impaired. An abnormality of the main intestinal fructose transporter proteins has been proposed as a cause for fructose malabsorption. However the underlying molecular mechanism for this remains unclear. In this study, we investigated whether carbohydrate response element-binding protein...

article

Mo1954 - Histamine-Mediated Macrophage Activation is Required for the Homeostasis of Gastric Epithelial Cell Proliferation

Kwang Hui Kim, Yura Lee, Buhyun Lee, Timothy C. Wang, more

Gastroenterology > 2018 > 154 > 6(S1) > S-863

article

Sa1613 - Expression of Lrig1, a Negative Regulator of Egfr, is Dynamically Altered in Different Stages of Gastric Carcinogenesis

Hyunji Kim, Sungsook Yu, Yejin Cho, Robert J. Coffey, more

Gastroenterology > 2018 > 154 > 6(S1) > S-330

article

Sa1610 - Expression of Dclk1 Isoforms Regulate Epithelial Mesenchymal Transition in Gastric Carcinogenesis

Sungsook Yu, Hyekyeong Hwang, Kwang Hui Kim, Hyunji Kim, more

Gastroenterology > 2018 > 154 > 6(S1) > S-329

article

Sa1612 - Loss of Rab25 Aggravates Lesions of Gastric Mucosa in Histidine Decarboxylase Deficient Mice.

Haeng Dueng Jeong, Yura Lee, Buhyun Lee, Kwang Hui Kim, more

Gastroenterology > 2018 > 154 > 6(S1) > S-330

article

582 - Loss of Human Epididymis Protein 4 Inhibits Oxyntic Atrophyinduced Spasmolytic Polypeptide Expressing Metaplasia

Buhyun Lee, Sungsook Yu, Kwang Hui Kim, Haeng Dueng Jeong, more

Gastroenterology > 2018 > 154 > 6(S1) > S-121

article

Tu1281 - The Protective Role of Nadph Oxidase 4 in Dextran Sulfate Sodium-Induced Colitis Mouse Model

Yura Lee, Sungsook Yu, Kwang Hui Kim, Yejin Cho, more

Gastroenterology > 2018 > 154 > 6(S1) > S-923

article

Investigation of dermal toxicity of ionic liquids in monolayer-cultured skin cells and 3D reconstructed human skin models

Jee-hyun Hwang, Hyeonji Park, Dal Woong Choi, Ki Taek Nam, more

Toxicology in Vitro > 2018 > 46 > C > 194-202

Ionic liquids have gained increasing attention in the chemical industry as potential green substitutes for traditional solvents. However, little is known about toxicity of ionic liquids on the skin, a major exposure portal to toxic substances. Here, we evaluated dermal toxicity of ionic liquids using human keratinocyte and fibroblast cell line, 3D reconstructed human epidermis, and full-thickness...

article

Neuronal Nitric Oxide Synthase Is a Novel Biomarker for the Interstitial Cells of Cajal in Stress-Induced Diarrhea-Dominant Irritable Bowel Syndrome

Da Eun Jang, Ji Hyun Bae, Yoo Jin Chang, Yoon Hoo Lee, more

Digestive Diseases and Sciences > 2018 > 63 > 3 > 619-627

Background Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder involving changes in normal bowel movements. The pathophysiology of IBS is not clearly understood owing to the lack of identifiable pathological abnormalities and reliable biomarkers. Aim The aim of this study was to discover the novel and reliable biomarker for IBS. Method In this study, neonatal maternal separation...

article

CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice

Joo-Il Kim, Jin-Sung Park, Jina Kwak, Hyun-Jin Lim, more

Laboratory Animal Research > 2018 > 34 > 4 > 302-310

CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein α (SIRPα) on macrophages and thereby inhibits phagocytosis of RBCs. Recently, we generated a novel C57BL/6J CD47 knockout (CD47^-/- hereafter) mouse line by employing a CRISPR/Cas9 system at Center for Mouse Models...

article

Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis

Hyejeong Kim, Haengdueng Jeong, Yejin Cho, Jaehoon Lee, more

Laboratory Animal Research > 2018 > 34 > 4 > 257-263

Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and plays a critical role in the differentiation of gastric glands. Since approximately 50% of all human gastric cancers are associated with decreased TFF1 expression, it is considered a tumor suppressor gene. Tff1 deficiency in mice results in histological changes in the antral and pyloric gastric mucosa,...

article

CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice

Joo-Il Kim, Jin-Sung Park, Hanna Kim, Soo-Kyung Ryu, more

Laboratory Animal Research > 2018 > 34 > 4 > 166-175

Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunodeficiency (SCID) in humans. Rag-2 knockout mice created using homologous recombination in ES cells have served as a valuable immunodeficient platform, but concerns have persisted on the specificity...

article

In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe

Xiaoqiang Chen, Dayoung Lee, Sungsook Yu, Gyoungmi Kim, more

Biomaterials > 2017 > 122 > C > 130-140

The development of multifunctional reagents for simultaneous specific near-infrared (NIR) imaging and phototherapy of tumors is of great significance. This work describes the design of a cathepsin B-activated fluorescent probe (CyA-P-CyB) and its applications as an NIR imaging probe for tumor cells and as a phototherapy reagent for tumors. In vitro experiments demonstrated that CyA-P-CyB was activated...

article

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

Da Hyun Lee, Dai Hoon Han, Ki Taek Nam, Jeong Su Park, more

Free Radical Biology and Medicine > 2016 > 99 > C > 520-532

Oxidative stress is important for the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a chronic disease that ranges from hepatic steatosis to nonalcoholic steatohepatitis (NASH). The nuclear factor erythroid 2-related factor 2–Kelch-like ECH associated protein 1 (Nrf2-Keap1) pathway is essential for cytoprotection against oxidative stress. In this study, we found that oxidative stress or...

article

Dynamic Expansion of Gastric Mucosal Doublecortin-Like Kinase 1–Expressing Cells in Response to Parietal Cell Loss Is Regulated by Gastrin

Eunyoung Choi, Christine P. Petersen, Lynne A. Lapierre, Janice A. Williams, more

The American Journal of Pathology > 2015 > 185 > 8 > 2219-2231

Doublecortin-like kinase 1 (Dclk1) is considered a reliable marker for tuft cells in the gastrointestinal tract. We investigated the dynamic changes of tuft cells associated with mouse models of oxyntic atrophy and metaplasia in the stomach. Increases in the numbers of Dclk1-positive tuft cells were observed in several models of parietal cell loss. However, the expanded population of Dclk1-expressing...

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INFONA - science communication portal

Search results for: Ki Taek Nam

RAB25 coordinates filaggrin‐containing keratohyalin granule maturation and affects atopic dermatitis severity

Reactivity Differences Enable ROS for Selective Ablation of Bacteria

Reactivity Differences Enable ROS for Selective Ablation of Bacteria

Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking

Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine

ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome

Mo1954 - Histamine-Mediated Macrophage Activation is Required for the Homeostasis of Gastric Epithelial Cell Proliferation

Sa1613 - Expression of Lrig1, a Negative Regulator of Egfr, is Dynamically Altered in Different Stages of Gastric Carcinogenesis

Sa1610 - Expression of Dclk1 Isoforms Regulate Epithelial Mesenchymal Transition in Gastric Carcinogenesis

Sa1612 - Loss of Rab25 Aggravates Lesions of Gastric Mucosa in Histidine Decarboxylase Deficient Mice.

582 - Loss of Human Epididymis Protein 4 Inhibits Oxyntic Atrophyinduced Spasmolytic Polypeptide Expressing Metaplasia

Tu1281 - The Protective Role of Nadph Oxidase 4 in Dextran Sulfate Sodium-Induced Colitis Mouse Model

Investigation of dermal toxicity of ionic liquids in monolayer-cultured skin cells and 3D reconstructed human skin models

Neuronal Nitric Oxide Synthase Is a Novel Biomarker for the Interstitial Cells of Cajal in Stress-Induced Diarrhea-Dominant Irritable Bowel Syndrome

CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice

Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis

CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice

In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

Dynamic Expansion of Gastric Mucosal Doublecortin-Like Kinase 1–Expressing Cells in Response to Parietal Cell Loss Is Regulated by Gastrin

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