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Digoxin and ouabain are cardioactive glycosides, which inhibit the Na + /K + -ATPase pump and in this way they increase the intracellular concentration of cytosolic calcium ([Ca ++ ] i ). They are also strong inducers of the P-glycoprotein (Pgp), a transmembrane transporter which extrudes several drugs, including anticancer agents like doxorubicin. An increased amount...
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