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Background Low expression of E2F3a and caspase 8 associated protein 2 (CASP8AP2) are associated with poor prognosis of childhood acute lymphoblastic leukemia (ALL). Methods Dual-luciferase reporter assay and wild type as well as four mutated types of reporter plasmids were used to demonstrate the activation of E2F3a on CASP8AP2 transcription. The direct binding of E2F3a with the promoter of CASP8AP2...
ObjectivesTo study E2F3a expression and its clinical significance in children with acute lymphoblastic leukemia (ALL).
MethodsWe quantified E2F3a expression at diagnosis in 148 children with ALL by real‐time PCR. In the test cohort (n = 48), receiver operating characteristic (ROC) curve was used to find the best cut‐off point to divide the patients into E2F3a low‐ and high‐expression groups. The...
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