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Background Let-7 is one of the earliest discovered microRNAs(miRNAs) and has been reported to be down-regulated in multiple malignant tumors. The effects and molecular mechanisms of let-7i in bladder cancer are still unclear. This study was to investigate the effects and potential mechanisms of let-7i on bladder cancer cells. Methods Total RNA was extracted from bladder cancer cell lines. The expression...
BackgroundNeonatal Bacillus Calmette–Guérin (BCG) vaccination induces vigorous T‐helper type 1 (Th1) responses and inhibits allergy‐related airway dysfunction, but the exact mechanisms remain unclear. The objective of this study was to address where the Th1 cells induced by neonatal BCG vaccination are generated and stored, and how they are recruited into the inflamed airway for the prevention of...
Using in situ nanoindentation, we studied the migration mechanisms of Σ3{112} incoherent twin boundary (ITB) in epitaxial nanotwinned Cu films. ITBs migrate by propagation of steps or disconnections with step heights of three or multiples of three {111} interplanar distances, and the migration may lead to the detwinning of nanotwins. The transmission of a glide dislocation across an ITB is shown to...
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