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We evaluated the in vivo anti-tumor effect of polyethylene glycol-modified liposomal doxorubicin (PEG liposomal DOX) in the DOX-resistant Colon-26 cancer cells (C26/DOX)-bearing mice model. IC 50 value of DOX to C26/DOX in vitro (40.0 µM) was about 250 times higher than that to control C26 (C26/control) (0.15 µM). However, in vivo anti-tumor effect of PEG liposomal DOX was similar in both...
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