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Mechanical stress plays an essential role in bone homeostasis by regulationg both bone formation and resorption. We have previously shown that cyclic stretch loading to MC3T3-E1 cells induced the expression of two bone remodeling related genes, Fn14 and MCP-3, through activation of ASK1 (a MAPKKK)/JNK and ASK1/p38 pathways, respectively. Here we show that cyclic stretch loading also induced the activation...
Prosthetic hip joint dislocation phenomenon is generated by the hip joint simulator and the effect of the femoral head diameter is studied under the same condition which is similar to the condition in daily activities. Impedance control is applied to control the hip joint motion and the joint contact force simultaneously in order to take into account the constraint caused by surrounding tendons, muscles,...
Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. We previously investigated the effects of loading of cyclic mechanical stretch on the activaties of JNK and p38 in MC3T3-E1 osteoblastic cells, and observed that JNK and p38 were activated by the mechanical stress. The patterns...
Total hip arthroplasty (THA) is performed to replace all or part of a human hip joint with an artificial joint for patients who have rheumatoid arthritis or osteoarthritis of the hip joint. Although THA might result in postoperative complications of dislocation, wear and/or loose, their mechanisms have not been analyzed enough. We have developed an artificial-hip-joint simulator that can generate...
Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. In this study we determined the effects of cyclic mechanical stretch of varying magnitudes and durations on the activation of JNK and p38 in MC3T3-E1 cells. Phosphorylation of both JNK and p38 was observed 5 min after the onset...
Ca2+ activated single glycerinated muscle fibers were stretched by 3% of its slack length L0 with moderate velocities ranging from 0.015 to 0.15L0, and muscle fiber stiffness during and after stretch was measured by applying sinusoidal vibrations (peak-to-peak amplitude, 0.1% of L0, 2 kHz). During a single stretch, the fiber was first stretched by 1.5% with a velocity, and then it was further stretched...
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