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Background: A downregulation of I 2 -imidazoline binding sites has been reported in frontal cortices of depressed suicide victims, according to I 2 -radioligand binding and confirmed by Western blotting. We now report Western blots of imidazoline receptor proteins in hippocampi of subjects with and without depression at the time of death.Methods: Postmortem diagnoses were obtained...
A substantial number of studies have demonstrated increased imidazoline receptors (I 1 binding sites) on platelets of depressed patients and downregulation following antidepressant treatments. Herein, imidazoline receptor binding protein (IRBP) antiserum was used to quantify imidazoline receptors on platelets of depressed patients before and after treatment with the atypical aminoketone antidepressant,...
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