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To evaluate the magnitude of chemical exchange effects and R1ρ dispersion in muscle and their relationship to tissue sodium levels with aging.Seven healthy volunteers (aged 24 to 87years, median age 47) underwent MRI to assess tissue sodium levels and water T1ρ values at different spin-locking frequencies in calf muscles. T1ρ values at each locking field were computed based on a three-parameter mono-exponential...
To develop a method for estimating metabolite concentrations using phased-array coils and sensitivity-encoded (SENSE) magnetic resonance spectroscopic images (MRSI) of the human brain.The method is based on the phantom replacement technique and uses receive coil sensitivity maps and body-coil loading factors to account for receive B 1 inhomogeneity and variable coil loading, respectively....
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