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β‐catenin is a multifunctional protein that not only acts in the canonical Wnt/β‐catenin pathway to regulate gene expression but also binds to cadherin proteins in adherens junctions, where it plays a key role in regulating cytoskeleton linked with these junctions. Recently, evidence has been presented indicating an essential role for β‐catenin in regulating the trafficking of insulin vesicles in...
Both insulin and leptin action in the brain are considered to involve activation of phosphoinositide 3‐kinase (PI3K), although the roles of different PI3K isoforms in insulin signalling in the hypothalamus are unknown. In the present study, we characterised the roles of these isoforms in hypothalamic insulin and leptin signalling and investigated the cross‐talk of both hormones. To evaluate PI3K levels...
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