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Experimental sarcoplasmic reticulum damage induced by 3μM thapsigargin or 1μg/ml tunicamycin provoked viability loss of the cell population in approximately 72h. Release of cytochrome c from mitochondria was an early event and Bax translocation to the mitochondria preceded or was simultaneous with cytochrome c release. The release of cytochrome c was not related with mitochondria depolarization or...
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