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Progressive accumulation of amyloid-β (Aβ) is a pathological hallmark of Alzheimer's disease (AD). Aβ increases free radical production in neuronal cells, leading to oxidative stress and cell death. An intervention that would reduce Aβ-related neurotoxicity through free radical reduction could advance the treatment of AD. Notoginsenoside R1 (NR1), the major and most active ingredient in the herb Panax...
Both of ceramide and PPARγ ligand can trigger cancer cell apoptosis. We here show that C2-ceramide can modulate PPARγ expression level and its transcriptional activity and results in apoptosis in HT29 cells. Administration of PPARγ specific antagonist GW9662 partially prevents HT29 cells from apoptosis. Furthermore, MAP kinase pathway provided a potential modulation mechanism for PPARγ pathway related...
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