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Hypoxia experienced by the fetus is beli ved to be a major cause of disturbed CNS function during childhood. During perinatal hypoxia endogenous opioids are released in large amounts and the developing brain in the last week of gestation may be influenced by circulating opioids, down-regulates n-opioid receptors in neonatal brain. The opioid antagonist, Naltrexone (N) blocks opiate receptors in the...
Hypoxia induces an elevation of excitotoxic amino acid concentrations and may influence hypoxic-in- duced basal ganglia injury. During pregnancy, hypoxia as the destructive factor of CNS alters concentration and mental retardation during childhood. The NMDA antagonist, MK-801, is known to block the effect of amino acids and protect the developing brain against hypoxic insults. To test the hypothesis...
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