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The blood platelet activation plays an important role in haemostasis. Mechanism of
platelet activation is accompanied by intracellular signal transduction pathways that are
responsible for different physiological responses of platelets: changes in platelet shape, release
of their granule contents and platelet aggregation. Platelets circulate in vivo together with huge
masses of erythrocytes and...
The effects of cisplatin (cis-diamminedichloroplatinum II, CDDP) and transplatin (transdiamminedichloroplatinum,
TDDP) at concentrations o f 0.1, 1 and 10 /¿M on platelet
cytoskeleton protein composition were studied in vitro. Cisplatin and transplatin were found
to cause the changes of cytoskeleton proteins. On the other hand in the presence of CDDP
(20 μM) the percent of G-actin was reduced.
The effects of cisplatin and transplatin on the ADP (10 μM) - induced aggregation and
secretion in vitro were studied. Platinum compounds had an inhibitory effect on ADP-induced
platelet aggregation and secretion of adenine nucleotides and proteins from blood platelets.
Cisplatin and transplatin also changed the metabolism of endogenous platelet arachidonate
and thromboxne A2 synthesis in...
The effects of cisplatin (cisdiamminedichloroplatinum II) at the concentration of 20 µM
and transplatin (transdiamminedichloroplatinum II) at the concentrations of 20 µM and 200 and transplatin at the concentration of 200 µM were found to cause a significant increase of
thiobarbituric add reactive substances (TBARS).
We have demonstrated, that cisplatin - induced platelet lipid peroxidation was...
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