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Here we explored a contribution of fusion proteins to stalk formation, the first stage of membrane fusion, and considered two likely mechanisms, by which these proteins could influence the membrane transformation. One mechanism represents the induction of spontaneous membrane curvature, while another is membrane disturbance by a force generated by attached proteins. The energy barrier arising due...
This paper studies change of membrane shape at the initial stage of the fusion process due to the fusion proteins inducing spontaneous curvature in the membrane. As protein inclusions are embedded into the membrane, a highly curved surface forms in the center of the membrane; it facilitates the formation of short-lived hydrophobic defects and leads to the merger of the contact monolayers of the membranes...
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