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Ionotropic purine P2X receptors play important roles in the processes of generation and transmission of nociceptive signals. The relative roles of certain subtypes of these receptors in the above processes have not, however, been finally elucidated. To a significant extent, this is explained by the absence of selective modulators of their functioning. In this study, we examined the effects of a nonhydrolyzable...
We examined effects of purotoxin 1 (PT1), a component of the venom of Geolycosa spiders, on a few voltageand ligand-operated ion channels present in the plasma membrane of sensory neurons from the rat dorsal root ganglia (DRGs). Purotoxin 1 in a 100 nM concentration evoked no changes in ion currents through voltage-operated sodium, potassium, and calcium channels in the membranes of isolated sensory...
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