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Drug delivery to solid tumors can be expressed physically using biomechanical phenomena such as convection, diffusion of drug in extracellular matrices, and drug extravasation from microvessels. Applying computational methods to solve governing conservation equations clarifies the mechanisms of drug delivery from the injection site to a solid tumor. In this study, multiple tumor geometries were obtained...
A solid tumor is investigated as porous media for simulation fluid flow through it. Most of the research used Darcy model for porous media. In Darcy model the fluid friction is neglected and some simplified assumption is implemented. In this study the effect of these assumptions is studied by considering Brinkman model. A multi scale mathematical method which calculates fluid flow to a solid tumor...
Interstitial fluid flow has been studied by many cancer researchers for investigation on the effect of interstitial flow on drug delivery. This paper formulates blood flow through a capillary network induced by a solid tumor and fluid flow in a tumor's surrounding tissue and investigates the effects of consideration a remodeled network and adaptability of capillary on interstitial flow. Numerical...
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