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Computational grids have been at the forefront of e-science supercomputing for several years now. Many issues have been settled over the years, but some may only appear to be so. One of these issues is firewall traversal. Many solutions have been proposed and developed. We have developed two such solutions ourselves: Remus and Romulus, but like all other solutions, they are limited in application...
Computational grids are now mainstream facilities for e-research worldwide. While enterprise grids exist within organizations, national grids have become common, usually consisting of government as well as academic facilities. Such facilities are not uncommonly lenient with blanket policies to allow inbound and outbound grid traffic. This is far from ideal, from a security perspective, but given the...
In this study, a computational framework combining state-of-the-art cardiac simulation software and Grid computing is used to investigate the impact of the block of the HERG current on the ECG waveform using state-of-the-art 3D ventricular models of electrophysiology. The technology developed enables (i) automated parameter sweeping using multiscale models (from ion channel to ECG) and (ii) reduced...
Applications that span multiple virtual organizations (VOs) are of great interest to the eScience community. However, recent attempts to execute large-scale parameter sweep applications (PSAs) with the Nimrod/G tool have exposed problems in the areas of fault tolerance, data storage and trust management. In response, we have implemented a task-splitting approach, which breaks up large PSAs into a...
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