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Fumonisin B 1 is a mycotoxin produced by Fusarium verticillioides, frequently associated with corn. It produces species-specific and organ-specific toxicity, including equine leukoencephalomalacia, porcine pulmonary edema, and hepatic or renal damage in most animal species. Fumonisin B 1 perturbs sphingolipid metabolism by inhibiting ceramide synthase. Our previous studies in male...
Fumonisin B 1 (FB 1 ), a mycotoxin from Fusarium verticillioides, disrupts sphingolipid metabolism by inhibiting ceramide synthase leading to modulation of cytokines including tumor necrosis factor (TNF) α. Current study investigated the effect of interrupting TNFα signaling, known to be involved in FB 1 hepatotoxicity. Male C57BL/6N mice were injected intravenously once with...
Fumonisin B 1 , a common mycotoxin produced by Fusarium verticillioides found in corn, causes several fatal animal diseases. Liver and kidney are target organs of fumonisin B 1 in laboratory animals, but primary rodent hepatocytes and liver slices were resistant to fumonisin B 1 -induced cytotoxic effects. We have shown that fumonisin B 1 induces expression of tumor...
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