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Recent studies show that drug-disease associations provide important information for drug discovery and drug repositioning. Wet experimental identification of drug-disease associations is time-consuming and labor-intensive. Therefore, the development of computational methods that predict drug-disease associations is an urgent task. In this paper, we propose a novel computational method named NTSIM,...
human splicing branchpoints are functional elements of the alternative splicing, and the study on branchpoints can help to understand the mechanism of human pre-mRNA transcript. There are a large number of human splicing branchpoints, but the wet methods that identify branchpoints are labor-intensive and time-consuming. In this paper, we utilize machine learning techniques to build models for the...
In the biomedicine domain, a large number of papers are published every day, which is crucial to search for the relevant answers for the user's query. However, documents are not exactly what the users want. Instead, snippets, small segments from the documents, are more proper to meet the requirement of the users. Hence, this paper proposes a biomedical snippet retrieval framework to exactly locate...
This paper proposes the theory and design of circular higher-order microphone arrays for 3D sound field analysis using spherical harmonics. Through employing the spherical harmonic translation theorem, the local spatial sound fields recorded by each higher-order microphone placed in the circular arrays are combined to form the sound field information of a large global spherical region. The proposed...
Since the consumption of air conditioning devices takes a significant proportion in the electricity demand, implementation of appropriate control strategies will conserve a considerable amount of energy. A proper space thermal model is required for any control strategy, which is built on the accurate identification of unknown parameters. A first-order lumped parameter model is employed to depict space...
The prediction of T-cell epitopes is of great help for facilitating vaccine design and understanding the immune system. In the bioinformatics, the MHC-binding peptides are defined as the T-cell epitopes, which will trigger the immune response to the antigens. However, binding peptides cannot necessarily activate the immune response, namely non-immunogenic. Until now, little attention has been paid...
Based on the Rayleigh-Plesset homogeneous hypothesis and the compressible mixture multiphase model, three-dimensional CFD numerical calculation model of high-speed projectile under water was built. Compared with the empirical formula, the consistency between it and results from model on the conditions of zero-angle attack and fixed cavitation number is good. Therefore, the validity of numerical method...
Multi-color effect in Chinese painting has a special feature. To simulate its complex result of different color mixture in proportion, we introduced the calculation method of color mixture based on CIE-Lhs color model, and success to simulate the effect of pigments mixture superposition which fitting for the feeling of people through experimental analysis. Based in the method of multi-color effect,...
Micro-channel cooler is a very promising approach to meet the requirements of microelectronics package cooling. A lot of investigations about micro-channels have been undertaken in the past years. A silicon micro-channel can remove 790 W/cm2 heat with a temperature rise of 71 degrees between the substrate and the coolant. The width and height of the silicon channel are 50 mum and 302 mum separately...
The Streamline Texture Synthesis (STS) method uses a different 1D texture to texture map each streamline and streamline textures are synthesized. The Enhanced STS (ESTS) adjusts the width of a streamline based on the critical point and maps several 1D textures to a streamline in order to accelerate computing. ESTS can also simulate animations and visualize 2D unsteady or 3D surface flows. The analyzed...
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