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In the present study, we examined the role of Staphylococcus aureus protein A (SpA) in inducing inflammatory response in human corneal epithelial cells (HCECs). Exposure of HCECs to SpA induces rapid NF-κB activation and secretion of proinflammatory cytokine/chemokines (TNF-α and IL-8) in both concentration and time-dependent manner. Challenge of HCECs with live SpA −/− mutant S. aureus strains...
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