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To investigate complex electrophysiological behaviour (such as reentrant cardiac arrhythmias) in the setting of the complex anatomy of the heart, the use of a simplified model is computationally more effective. In this study, the Rogers-modified FitzHugh-Nagumo model was further modified to allow control of action potential upstroke velocity, conduction velocity, action potential duration and refractory...
Idiopathic short QT (SQT) syndrome is a recently identified, genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death. In this computer simulation study, we identify the mechanisms by which cellular electrophysiological changes in the SQT syndrome associated with V307L KvLQT1 (KCNQ1) gene mutation (the gene coding...
We have developed a three-dimensional computational wedge model of canine cardiac ventricular wall electro-physiology that incorporates biophysically detailed, spatially heterogeneous excitation, and high-resolution geometry and fibre orientation. Isolated cell model electrophysiological characteristics reproduce the experimentally observed characteristics under control conditions, and under conditions...
Sinoatrial (SA) node, the pacemaker of the heart, is a structurally and functionally complex tissue. The role of this complexity in initiation and conduction of the pacemaker activity is not fully understood. Computer modeling provides a powerful alternative way to experiment in studying complex cardiac phenomena. In this work we combine histological, immunochemical, electrophysiological data with...
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