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Background
The generation of the tolerogenic dendritic cells (DC) is not fully understood yet. Forkhead box protein‐3 (Foxp3) is an important molecule in the immune tolerance. This study tests a hypothesis that DCs express Foxp3, which can be upregulated by Staphylococcal enterotoxin B (SEB).
Methods
The expression of Foxp3 by DCs was evaluated by real‐time RT‐PCR, Western blotting, flow cytometry,...
To cite this article: Chen X, Song C‐H, Liu Z‐Q, Feng B‐S, Zheng P‐Y, Li P, In SH, Tang S‐G, Yang P‐C. Intestinal epithelial cells express galectin‐9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine. Allergy 2011; 66: 1038–1046.
AbstractBackground and aims: Mechanisms in sustaining the allergic hypersensitivity status in the body are unclear...
To cite this article: Liu T, Xie C, Chen X, Zhao F, Liu A‐M, Cho D‐B, Chong J, Yang P‐C. Role of muscarinic receptor activation in regulating immune cell activity in nasal mucosa. Allergy 2010; 65: 969–977.
AbstractBackground: The prevalence of airway inflammatory disorders keeps rising; its pathogenic mechanism is still not fully understood.Objective: The present study aimed to investigate the...
To cite this article: Zhao C‐Q, Li T‐L, He S‐H, Chen X, An Y‐F, Wu W‐K, Zhou X‐H, Li P, Yang P‐C. Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cells. Allergy 2010; 65: 986–995
AbstractBackground: Specific immunotherapy (SIT) is the only curable remedy for allergic disorders currently; however, the underlying mechanism is not fully understood yet...
. Dendritic cells (DC) are specialized antigen-presenting cells. Bone marrow monocytes have been widely used to generate murine myeloid DC. We found that mouse macrophages derived from bone marrow CD11b+ monocytes influenced the differentiation of these precursors into DC. Modulation of differentiation was demonstrated by the down-regulation of CD11c, CD40, and CD86 expression and by IL-12 production...
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