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Cell-penetrating peptide (CPP) was linked to insulin to form insulin–CPP hybrids. The intestinal absorption efficiency of CPP hybridized insulin was 6–8 times increased compared to normal insulin as tested on Caco-2 cell monolayer, a widely used in vitro model for intestinal absorption. Insulin–CPP hybrid transportation seemed to be through an active and transcytosis-like mechanism. Importantly, insulin...
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