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Congestive heart failure is a clinical syndrome whose hallmarks are fatigue and dyspnea. Common pathophysiologic features of heart failure include changes in the structure of the left ventricle of the heart, function, and neurohormonal activation. A recapitulation of the heart failure phenotype in a large animal model can make it possible to translate basic science discoveries into clinical therapies...
Glycerol can be an efficient glucogenic substrate, if it is absorbed directly from the rumen. In that case its advantage consists in entering the neoglucogenic pathway as phosphate triose, without entering the Krebs cycle. A cow in negative energy balance activates this extra pathway, using glycerol obtained by the hydrolysis of triglycerides. This way of absorbing glycerol is superior to its fermentation...
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