The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
BACKGROUNDNeuroendocrine differentiation (NED) is one of the mechanisms underlying development of castration‐resistant prostate cancer (CRPC). In this study, we investigated IL‐6‐induced NED in two LNCaP sublines.
METHODSLNCaP‐S17, an LNCaP subline that secretes IL‐6, and LNCaP‐C3, a control subline that does not express IL‐6, were analyzed for IL‐6‐induced NED, activation of JAK2 and STAT3 pathways,...
BACKGROUNDTreatment for primary prostate cancer (CaP) is the withdrawal of androgens. However, CaP eventually progresses to grow in a castration‐resistant state. The mechanisms involved in the development and progression of castration‐resistant prostate cancer (CRPC) remain unknown. We have previously generated LNCaP‐IL6+ cells by treating LNCaP cells chronically with interleukin‐6 (IL‐6), which have...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.