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Neurones in the centrally projecting Edinger–Westphal nucleus (EWcp) are the main site of urocortin 1 (Ucn1) synthesis in the mammalian brain, and are assumed to play a role in the stress response of the animal. Because endocannabinoid signalling has also been strongly implicated in stress, we hypothesised that endocannabinoids may modulate the functioning of the urocortinergic EWcp. First, using...
The gonadotrophin‐releasing hormone (GnRH) secreting neurones, which form the final common pathway for the central regulation of reproduction, are directly targeted by kisspeptin (KP) via the G protein‐coupled receptor, GPR54. In these multiple labelling studies, we used ovariectomised mice treated with 17β‐oestradiol (OVX + E2) or vehicle (OVX + oil) to determine: (i) the ultrastructural characteristics...
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