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Prevention of hepatitis B virus (HBV) transmission from infected mothers to their newborns is critical to HBV control and eventual eradication. Mother-to-child perinatal transmission causes the highest chronic carrier rate (>85%) with a high rate of subsequent chronic liver disease and hepatocellular carcinoma. This risk is reduced by 90% with HBV vaccine given along with hepatitis B immune globulin...
ObjectiveHepatitis B virus (HBV) inactive carriers are HBV e antigen (HBeAg)‐negative patients with normal alanine aminotransferase (ALT) levels and HBV DNA of ≤ 10 000 copies/mL. We aimed to determine the clinical impact of ALT and HBV DNA elevations during the course of HBV infection.
MethodsFrom January 1989 to January 2012, 146 inactive carriers were prospectively followed every 6–12 months with...
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