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The ultra rapid potassium current (IKur) is an attractive pharmacological target in atrial fibrillation (AF) management due to its atrial specific nature. An experimentally based 78% IKur reduction was incorporated into a human atrial action potential (AP) model under sinus rhythm (SR) and atrial fibrillation (AF) conditions. Its effects on cell and tissue level electrical activity were simulated...
We computationally evaluated the functional roles of atrial fibrillation induced electrical remodelling (AFER) on human atrial electrical excitations at cellular, tissue and whole organ levels. Our results show that AFER produced a dramatic reduction in action potential duration, slowing down of intra-atrial conduction, decrease in tissuepsilas temporal vulnerability, but remarkable increase in tissuepsilas...
We have developed a three-dimensional computational wedge model of canine cardiac ventricular wall electro-physiology that incorporates biophysically detailed, spatially heterogeneous excitation, and high-resolution geometry and fibre orientation. Isolated cell model electrophysiological characteristics reproduce the experimentally observed characteristics under control conditions, and under conditions...
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