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Functional roles of ionic currents in a membrane delimited sino-atrial node (SAN) cell model were investigated. Ionic currents were blocked and intracellular calcium ([Ca2+]i) buffered to study their effects on action potential (AP) characteristics. The simulations revealed that blocking the hyperpolarization activated current and the T-type calcium current caused an increase of cycle length (CL)...
The E1784K mutation in SCN5A was reported as a phenotypic overlap between the Type 3 Long QT syndrome (LQT3) and the Brugada syndrome (BrS). However it is still unclear if the E1784K mutation-induced changes at ionic channel level is sufficient to account for the two phenotypic and how they affect ventricular excitation waves at tissue level. In this study, we used a biophysically detailed computer...
Atrial fibrillation (AF) is commonly associated with rapid excitation of the atria, but mechanisms of its initiation are unknown. Intracellular Ca2+ dynamics has been shown to affect cell restitution properties and, as a result, patterns of rapid reentrant excitation in ventricles at early stages of ventricular fibrillation. We study effects of the intracellular Ca2+ concentration changes on restitution...
Mechanical contraction alternans of the heart is associated with fatal cardiac death. It is manifested by T-wave alternans in the ECG, and is thought to be possibly related to intracellular Ca2+ transient alternans released from the sarcoplasmic reticulum (SR). However, it is unclear yet how beat-to-beat alternans of intracellular Ca2+ transient is produced. In this study investigated the mechanism(s)...
Sinoatrial (SA) node, the pacemaker of the heart, is a structurally and functionally complex tissue. The role of this complexity in initiation and conduction of the pacemaker activity is not fully understood. Computer modeling provides a powerful alternative way to experiment in studying complex cardiac phenomena. In this work we combine histological, immunochemical, electrophysiological data with...
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