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Currently there are no approved biomarkers for the pre‐symptomatic diagnosis of Alzheimer's disease (AD). Cathepsin‐D (Cat‐D) is a lysosomal protease that is present at elevated levels in amyloid plaques and neurons in patients with AD and is also elevated in some cancers. We have developed a magnetic resonance imaging (MRI)/fluorescent contrast agent to detect Cat‐D enzymatic activity. The purpose...
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