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Bone fragility involved in diseases such as osteoporosis implicates many mechanisms at the cellular level. It was recently shown that the lacunar-canalicular network interconnecting osteocytes has a major role in mechanosensitivity. So far, this system has only been studied from 2D microscopic images. In a previous work, we demonstrated the feasibility of synchrotron radiation micro-CT with a voxel...
Analysis of bone microvascularization has generally been performed from 2D histology. The method proposed in this study enables for the first time to simultaneously analyze, in 3D, the microvascularization and bone microstructure in a rat model. The method is based on the use of quantitative synchrotron micro-computed tomography (SR-μCT) coupled to an automatic image analysis procedure. It was applied...
A method for simultaneous 3D imaging and analysis of microvascularization and bone microstructure in rat bone is presented. The method is based on the use of quantitative synchrotron micro-computed tomography (SR-??CT) coupled to an automatic image analysis procedure. Previously, analysis of bone microvascularization has generally been performed from 2D histology. The proposed method enables for the...
A new method for simultaneous 3D imaging and analysis of microvascularization and bone microstructure in rat bone is developed. The method is based on the use of quantitative synchrotron micro-computed tomography (SR-muCT) coupled to an automatic image analysis procedure. Analysis of bone microvascularization is generally performed from 2D histology. The proposed method enables for the first time...
Phase contrast provides new possibilities in X-ray imaging, offering up to 1000 times higher sensitivity than standard absorption contrast. In propagation based phase contrast imaging, a quantitative relationship exists between intensity in the image plane and the phase shift induced by the object. Inversion of this relationship is called phase retrieval. Used as input to a 3D tomographic reconstruction...
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