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BackgroundGender appears to play a role in incidence and disease course of multiple sclerosis (MS).
ObjectiveThe objective was to determine whether male and female patients with MS respond differently to interferon‐beta treatment in terms of reduction in relapse rates.
MethodsWe included all 2033 patients with relapsing–remitting MS who started treatment with interferon‐beta from 1996 to 2003, identified...
ObjectiveSingle nucleotide polymorphisms (SNPs) in the genes encoding interferon response factor (IRF)‐5, IRF‐8 and glypican‐5 (GPC5) have been associated with disease activity in multiple sclerosis (MS) patients treated with interferon (IFN)‐β. We analysed whether SNPs in the IRF5,IRF8 and GPC5 genes are associated with clinical disease activity in MS patients beginning de novo treatment with IFN‐...
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