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This study validated the use of mutant prevention concentration (MPC) and pharmacokinetic and pharmacodynamic (PK–PD) modeling approach for optimization of dose regimen of enrofloxacin to contain the emergence of Pasteurella multocida resistance. The PK and PD characteristics of enrofloxacin were investigated in buffalo calves after intramuscular administration at a dose rate of 12mg/kg. The concentration...
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