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Optically active alkane-6,8-diols have been both chemically synthesized and isolated from the flowers of Carthamus tinctorius. These alkane-6,8-diols were synthesized in moderate yields from a chiral β-ketosulfoxide in three steps, and showed inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced ear inflammation in mice. Natural syn-alkane-6,8-diols displayed a weaker effect compared...
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