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This paper describes a vapor detecting system that applies two robust biological elements: A biological nanopore formed in a lipid bilayer and a DNA aptamer. The principle of the sensor is as follows: 1) DNA aptamer selectively captures the target molecules, 2) builds up a molecular complex larger than the nanopore size, and 3) inhibits the ionic current through the nanopore by blocking. We integrated...
This paper presents a new method to fabricate 2-dimensional collagen sheets whose internal molecular structures form highly-aligned nanofibers in one direction. In this work, collagen nanofibers are self-aligned in fully 2-dimensional substrates by applying cyclic stretch during the gelation process of collagen solution, and the fabricated collagen sheets induce the alignment of cells without any...
This paper describes microfluidic logic gates which use DNA and biological nanopores. Single-stranded DNA (ssDNA) can pass through αHL, a biological nanopore, incorporated in bilayer lipid membranes (BLMs), whereas double-stranded DNA (dsDNA) cannot. In this study, these passing and non-passing phenomena were applied as the binary system and logic gates. Two types of ssDNA were used as inputs, while...
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