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Treatment with either haloperidol or sulpiride for 14 days increased the levels of Gsα and Giα in the rat hippocampus, but decreased those of Golfα and Giα in the rat striatum. Levels of Gqα/G11α and Goα were not affected by the drugs. These results demonstrate that haloperidol and sulpiride regulate G protein expression in the hippocampus and striatum quite differently.
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