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The allosteric modulation of G‐protein‐coupled receptors (GPCRs) by sodium ions has received significant attention as crystal structures of several receptors show Na+ ions bound to the inactive conformations at the conserved Asp2.50. To date, structures from 24 families of GPCRs have been determined, though mechanistic insights into Na+ binding to the allosteric site are limited. We performed hundreds‐of‐microsecond...
Allosterische Modulatoren In der Zuschrift auf S. 3102 nutzen D. Shukla et al. Markov‐Modelle zur Berechnung der freien Energiebarrieren für die Bindung eines Na+‐Ions an das allosterische Zentrum von 18 G‐Protein‐gekoppelten Rezeptoren.
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