The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Crystallization is a major separation process in the pharmaceutical industry. Most crystallizations are performed batchwise, but there is great incentive for switching to continuous operation. We have investigated the modeling, simulation, optimization, and robustness of a multi-segmented, multi-addition plug-flow crystallizer (MSMA-PFC). The design accepts multiple antisolvent flows along its length,...
This paper presents an output feedback nonlinear model-based control approach for optimal operation of industrial batch crystallizers. A full population balance model is utilized as the cornerstone of the control approach. The modeling framework allows us to describe the dynamics of a wide range of industrial batch crystallizers. In addition, it facilitates the use of performance objectives expressed...
A computationally efficient approach is presented that quantifies the influence of parameter uncertainties on the states and outputs of finite-time control trajectories for nonlinear systems, based on the approximate representation of the model via polynomial chaos expansion. The approach is suitable for studying the uncertainty propagation in open-loop or closed-loop systems. A quantitative and qualitative...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.