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Halogenated analogues of the neurotoxic alkaloid muscimol were prepared with fluorine, iodine or trifluoromethyl at the 4 position of the isoxazole ring system. These compounds were investigated as agonists for GABAA receptors. Only the C‐4 fluorine‐containing analogue proved to be an active compound in these assays. The fluoro analogue was less active than muscimol, however it showed differential...
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