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The dietary flavonoids apigenin, genistein and (−)-epigallocatechin gallate (EGCG) inhibited the activation by GABA (40μM) of recombinant human α1β2γ2L GABA A receptors expressed in Xenopus laevis oocytes with IC 50 values of 8, 30 and 15μM, respectively. Apigenin and genistein also acted as GABA antagonists at flumazenil-insensitive α1β2 GABA A receptors, indicating that they...
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