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G‐Quadruplex(es) (G4) are noncanonical nucleic‐acid structures found in guanine‐rich sequences. They can be targeted with small molecules (G4 ligands) acting as reporters, for tracking both in vitro and in cells. We explored the cellular localization of PhenDC3, one of the most powerful G4 ligands, by synthesizing two clickable azide and alkyne derivatives (PhenDC3‐alk, PhenDC3‐az) and labeling them...
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