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Intracellular target identification of microRNA (miRNA), which is essential for understanding miRNA-involved cellular processes, is currently the most challenging task in miRNA-related studies. Although bioinformatic methods have been developed as the most efficient strategy for miRNA target identification, high-throughput experimental strategies are still highly demanded. In this review paper, we...
Targeted delivery of microRNA (miRNA) mimics into specific cells/tissues and real‐time monitoring on the biological function of delivered miRNA mimics at molecular level represent two major challenges in the development of miRNA‐based therapeutics. Here we report a highly efficient method to address these two challenges simultaneously by using the self‐assembled nanocomplex formed by miRNA mimics...
MicroRNAs (miRNAs) can regulate gene expression at the post‐transcriptional level and have been implicated in the development of various human diseases, including cancer. The regulatory networks of miRNAs play a vital role not only in normal physiology but also in pathology and may represent novel targets for drug discovery. Regulation of miRNAs and the elucidation of miRNA networks will advance...
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