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The transforming growth factor-β (TGF-β) signaling pathway plays an important role in tumorigenesis by exerting either a tumor-suppressing or tumor-promoting effect. Long non-coding RNAs (lncRNAs), a newly discovered class of non-coding RNAs, have been widely studied in recent years and identified as crucial regulators of various biological processes, including cell cycle progression, chromatin remodeling,...
MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that regulate gene expression at the post-transcriptional level. Accumulating evidence indicated that miRNAs are aberrantly expressed in a variety of human cancers and crucial to tumorigenesis. We herein provide a brief review of miRNA biogenesis, function, deregulation and their possible role as oncogenes or tumor suppressors...
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