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Objective
Increased protein phosphatase magnesium‐dependent 1A (PPM1A) levels in patients with ankylosing spondylitis regulate osteoblast differentiation in bony ankylosis; however, the potential mechanisms that regulate osteoclast differentiation in relation to abnormal bone formation remain unclear. This study was undertaken to investigate the relationship of PPM1A to osteoclast differentiation...
ObjectiveInterleukin‐10 (IL‐10) is a pleiotropic immunoregulatory cytokine with a chondroprotective effect that is elevated in cartilage and synovium in patients with osteoarthritis. However, the role of IL‐10 during endochondral bone formation and its mechanism of action have not been elucidated.
MethodsIL‐10–/– mice and IL‐10–treated tibial organ cultures were used to study loss and gain of IL‐10...
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